Th1/17-Biased Inflammatory Environment Associated with COPD Alters the Response of Airway Epithelial Cells to Viral and Bacterial Stimuli

Table 4

Effects of a Th1/17-biased environment on mRNA responses of primary AECs to virus-like/bacterial stimuli.

Cytokines	LPS	Imiquimod	Poly I:C
IL6	↑	ns	↑
CXCL8	↑	ns	↑
TNF	ns	ns	↑
IL1β	ns	ns	↑
IFN-β1	ns	ns	ns

Table 4 summarizes the change in gene expression in AEC cultured in the presence of Th1/17 cytokines, relative to cells grown in media alone, following stimulation with LPS, imiquimod, and poly I:C, respectively ( for each group). The significant differences compared to cells cultured in media alone are shown as and . For example, first “↑” in the table represents that the increase in the expression of mRNA for IL6 in response to LPS was significantly greater in AEC cultured in a Th1/17-biased environment than the increase in the expression of mRNA for IL6 in response to LPS in AECs grown in the absence of Th1/17 cytokines.