Mediators of Inflammation / 2019 / Article / Tab 2

Research Article

Relation of Macrophage Migration Inhibitory Factor to Pulmonary Hemodynamics and Vascular Structure and Carbamyl-Phosphate Synthetase I Genetic Variations in Pediatric Patients with Congenital Cardiac Shunts

Table 2

Demographic, diagnostic, and hemodynamic variables in groups defined according to the CPSI T1405N polymorphism.

CPSI genotypes in the study
CC ()AC ()

Age, months9.9 (7.2-13.6)10.4 (7.2-15.0)0.726†
Gender, M : F6 : 197 : 90.326‡
Down syndrome, (%)16 (64.0)11 (68.8)0.754‡
Peripheral oxygen saturation (%)95 (94-97)93 (91-95)0.089†
Pulmonary-to-systemic blood flow ratio§2.43 (2.01-2.94)2.10 (1.65-2.66)0.341†
High-PBF patients : high-PVR patients18 : 77 : 90.070‡
Diagnosis0.110ǁ
 A, (%)1 (4,0)0 (0.0)
 B, (%)16 (64.0)6 (37.5)
 C, (%)7 (28.0)10 (62.5)
 D, (%)1 (4.0)0 (0.0)
Cardiac catheterizationCC ()AC ()
 Mean pulmonary arterial pressure (mmHg)61 (54-70)49 (41-58)0.031†
 Mean systemic arterial pressure (mmHg)68 (61-77)59 (51-68)0.107†
 Pulmonary vascular resistance ()7.98 (4.88-13.07)4.98 (3.98-6.24)0.039†
 Systemic vascular resistance ()14.94 (11.83-18.85)13.56 (11.00-16.71)0.536†
 Pulmonary vascular resistance while on inhaled nitric oxide ()5.35 (2.13-13.41)2.98 (2.03-4.39)0.114†

Numeric variables are expressed as geometric mean (95% CI). Mann-Whitney test; Chi-square test; ǁlikelihood ratio; §estimated by echocardiography. A: pretricuspid defects, B: posttricuspid defects except for atrioventricular septal defects, C: atrioventricular septal defects, D: conotruncal defects. CPSI: carbamyl-phosphate synthetase I.