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Authors | Year | Sample size | Monocyte subpopulation of interest | Main result | Reference |
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Jaipersad et al. | 2014 | 160 individuals with carotid artery stenosis | CCR2-expressing monocytes, subdivided into classical, intermediate, and nonclassical subsets | Classical CD14hiCD16-CCR2+ monocytes are associated with the degree of carotid stenosis and plaque neovascularization evidenced by CEUS | [63] |
Ammirati et al. | 2016 | 64 individuals with intermediate carotid artery stenosis | CD14+ monocytes subdivided into classical, intermediate, and nonclassical subsets | Total CD14+ monocytes and nonclassical CD14hiCD16- monocytes are reduced in subjects with higher CEUS-evidenced neovascularization | [64] |
Ammirati et al. | 2018 | 9 individuals with intermediate carotid artery stenosis | CD14+ monocytes subdivided into classical, intermediate, and nonclassical subsets | People with a stronger uptake of activated macrophage-specific radiotracer PK11195 had reduced circulating total CD14+ monocytes and nonclassical CD14hiCD16- monocytes | [65] |
Justo-Junior et al. | 2018 | 18 controls, 34 individuals with CVRF, 32 patients with stable angina, and 16 patients with unstable angina | Classical, intermediate, and nonclassical circulating monocytes | Intermediate CD14hiCD16+ monocytes were elevated in unstable angina patients. They also displayed high expression of PRRs | [22] |
Yamamoto et al. | 2016 | 389 CAD patients | Peripheral blood monocytes | A high monocyte count predicted future cardiovascular events in CAD patients | [66] |
Zhuang et al. | 2017 | 48 patients with unstable angina and 31 patients with STEMI | Classical, intermediate, and nonclassical monocytes | Patients with evidence of thin cap fibroatheroma on OCT had significantly mode circulating intermediate CD14hiCD16+ monocytes | [67] |
Lorenzen et al. | 2011 | 191 subjects undergoing hemodialysis | CD14+TLR4+ monocytes | No association between CD14+TLR4+ and cardiovascular deaths or cardiovascular events | [68] |
Collin et al. | 2015 | 23 patients with nonobstructive CAD undergoing IVUS | CD14+BAP+OCN+ monocytes | CD14+BAP+OCN+ monocytes correlate with the presence of a large necrotic core within coronary artery plaques | [70] |
Meeuwsen et al. | 2019 | 175 subjects undergoing carotid endarterectomy (85% symptomatic, 15% asymptomatic) | Total, classical, intermediate, and nonclassical monocytes | No association between monocyte subpopulations and plaque features of vulnerability. No association between monocyte subpopulations and major adverse cardiovascular events at 3 years of follow-up | [72] |
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