Metalloproteinases and their Inhibitors under the Course of Immunostimulation by CPG-ODN and Specific Antigen Inhalation in Equine Asthma

Table 1

Clinical score modified from Barton et al. [24].

		Score	Max. points
(1) Cough induction	No cough after manual compression of larynx	0	1
	Coughing during manual larynx compression	1
	Very frequent coughing	1
	Spontaneous coughing	1
(2) Dyspnoea at rest	Prolonged expiration	1	3
	Increased abdominal effort in expiration	1
	Sinking of the intercostal area	3
	Nostril flare	3
	Heaves line	3
	Anal pumping	3
(3) Respiratory rate	8-16/min	0	2
	17-23/min	1
	≥24/min	2
(4) Lung auscultation	Rattling	2	2
	Crackle	2
	Wheezing	2
(5) Tracheobronchoscopy	Significantly increased secretions with moderate viscosity	1	2
	Highly increased secretions with high viscosity	2
	Thickened carina of the trachea	1
(6) Cytology tracheal aspirate	Neutrophils <8%	0	3
	Neutrophils 8-15%	1
	Neutrophils 15-25%	2
	Neutrophils >25%	3
(7) Arterial blood gas	AaDo2: 0-7 mmHg	0	2
	AaDo2: 7-14 mmHg	1
	AaDo2: >14 mmHg	2

≤6 points: mild asthma, 6-10 points: moderate asthma, 11-15 points: severe asthma.