Metalloproteinases and their Inhibitors under the Course of Immunostimulation by CPG-ODN and Specific Antigen Inhalation in Equine Asthma

Table 2

Concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2 in tracheal aspirates from horses suffering from equine asthma of different disease severity (mild, moderate, and severe).

	Mild asthma ()	Moderate asthma ()	Severe asthma ()
MMP-2 (ng/ml)	14.05 (13.5 - 14.4)	15.43 (15.1 - 16.7)	18.38 (17.9 - 19.1)
MMP-9 (pg/ml)	271.89 (107.3 - 469.7)	536.97 (178.5 - 819.1)	916.77 (908.3 - 993.2)
TIMP-1 (ng/ml)	104.81 (56.0 – 108.7)	152.36 (103.3 – 163.1)	181.45 (165.0 – 191.0)
TIMP-2 (ng/ml)	101.07 (65.6 - 129.4)	104.22 (68.2 - 137.1)	165.99 (157.3 - 188.8)

The results are expressed as , median, and range. The statistical analysis was performed by the Kruskal-Wallis test, and indicates significant differences between different severity groups.