Cx43 Inhibition Attenuates Sepsis-Induced Intestinal Injury via Downregulating ROS Transfer and the Activation of the JNK1/Sirt1/FoxO3a Signaling Pathway

Figure 2

Cx43 inhibition with 18-α-GA attenuated CLP-induced intestinal injuries. (a) Small intestine tissue slices were stained with H&E. Rats were intraperitoneally pretreated with 18-α-GA (30 mg/kg/day) for 3 days before CLP surgery. (b) The histopathological score was estimated according to Chiu’s standard. (c–e) Levels of LDH, DAO, and iFABP in small intestine tissues. (f–h) Levels of LDH, DAO, and iFABP in serum. Data are shown as , -10 for each group; vs. the Sham group and vs. the CLP group. Vehicle control of 18-α-GA is DMSO.

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