Search for Novel Diagnostic Biomarkers of Prostate Inflammation-Related Disorders: Role of Transglutaminase Isoforms as Potential Candidates

Figure 1

TG4 and TG2 alternative splicing. (a) Alternative splicing in TG4 transcript occurs at the N-terminal domain, leading to the formation of three variants. The asterisks indicate the exon interested by the splicing mechanism for each variant. (b) The sequence corresponding to the catalytic core or to the β-barrel domains of TG2 is involved in the splicing events. The intron retention mechanism that leads to the formation of TG2_v2 affects the exon 10. Shown here is the GTP/GDP binding site that involves also few amino acids (aa) in the exon 4 (arrow). In yellow is the conserved sequence of the catalytic core, including the cysteine (in bold).

(a)

(b)