In Vivo Effects of Neostigmine and Physostigmine on Neutrophil Functions and Evaluation of Acetylcholinesterase and Butyrylcholinesterase as Inflammatory Markers during Experimental Sepsis in Rats

Table 1

Effects of various treatments on the clinical appearance score, breathing rate, and body weights during the observation period (results for physostigmine- and neostigmine-treated animals are combined as “treatment group”).

Clinical score	Time (hours)	Control ()	Treatment ()	Sham ()
Breathing rate (per min)	0
	15
	20
	24
Coat (0-3)	0
	15	^,$ ()	^,$ ()
	20	^,$ ()	^,$ ()
	24	^,$ ()	^,$ ()
Movement (0-3)	0
	15	^,$ ()	^,$ ()
	20	^,$ ()	^,$ ()
	24	^,$ ()	^,$ ()
Eyes (0-3)	0
	15	^,$ ()	^,$ ()
	20	^,$ (n = 9)	^,$ ()
	24	^,$ ()	^,$ ()
Weight (g)	0
	15
	20
	24

There was no significant difference of the breathing rates during the entire experiment in any group (). The body weights did not change over time in any group (). The clinical appearance scores for eyes, coat, and movement were significantly higher in the control and treatment group than in the sham group (^$ vs. the sham group). At and 24 h, the clinical appearance score was in the placebo group and treatment groups significantly higher than at ( vs. ). The data are displayed as the (SD). versus . ^$ versus the sham group.