In Vivo Effects of Neostigmine and Physostigmine on Neutrophil Functions and Evaluation of Acetylcholinesterase and Butyrylcholinesterase as Inflammatory Markers during Experimental Sepsis in Rats

Table 2

Results of blood gas analysis during the observation period of 24 h (results for physostigmine- and neostigmine-treated animals are combined as “treatment group”).

Blood gas analysis	Time (h)	Control ()	Treatment ()	Sham ()
pH	0
	15	()	()	^§, ()
	20	()	()	()
	24	()	()	^§ ()
Base excess (mmol/L)	0	()	()	()
	15	()	()	^§ ()
	20	- ()	()	^§ ()
	24	- ()	- ()	^§ ()
Lactate (mmol/L)	0	()	()	()
	15	()	()	()
	20	()	()	()
	24	()	()	^§ ()
Glucose (mg/dL)	0	()	()	()
	15	()	()	^§, ()
	20	()	()	^§, ()
	24	()	()	^§, ()

pCO₂, pO₂, K⁺, Na⁺, Ca²⁺, Cl⁻, Hb, CO-Hb, Met-Hb, hematocrit, and SO₂ did not change significantly during the entire experiment in any group (data not shown). The treated animals and the control group showed an increase of lactate levels over time, being significant at ( versus ). In the control group, base excess was significantly reduced at ( versus ), but not in the treated animals or the sham group. After 15 h, pH and base excess of the sham group were significantly higher than in the control and treatment groups (^§ versus placebo/treatment). Glucose levels significantly decreased over time in all groups ( versus ). At , glucose levels were significantly higher in the sham group than in the control and treatment groups (^§ versus control/treatment). The data are presented as the . versus ; ^$ versus the control.