Tissue Inhibitor of Metalloproteinase-2 Polymorphisms and Risk for HIV-Associated Neurocognitive Disorder
Table 4
Frequency distribution of haplotypes of TIMP-2 (-418G/C and 303G/A) polymorphisms among patients with HAND, without HAND, and healthy controls.
Haplotypes TIMP-2 (-418G/C and 303G/A)
Patients with HAND ()
Patients without HAND ()
value
OR (95% CI)
GG
0.61
0.66
1
Reference
CG
0.17
0.18
0.94
1.03 (0.52 - 2.02)
GA
0.15
0.10
0.19
1.70 (0.77 - 3.74)
CA
0.05
0.04
0.69
1.34 (0.32 - 5.63)
Haplotypes TIMP-2 (-418G/C and 303G/A)
Patients with HAND ()
Healthy controls ()
value
OR ( 95% CI)
GG
0.61
0.72
1
Reference
CG
0.17
0.10
0.04
2.55 (1.05 - 6.18)
GA
0.16
0.15
0.28
1.57 (0.69 - 3.59)
CA
0.05
0.01
0.15
4.75 (0.58 - 38.60)
Haplotypes TIMP-2 (-418G/C and 303G/A)
HIV patients ()
Healthy controls ()
value
OR ( 95% CI)
GG
0.66
0.72
1
Reference
CG
0.18
0.10
0.08
1.70 (0.94 - 3.08)
GA
0.10
0.15
0.61
0.84 (0.43 - 1.64)
CA
0.04
0.01
0.37
1.99 (0.45 - 8.77)
= total number of alleles, (%) = frequency of haplotypes; age-adjusted odds ratios and 95% CIs were derived from logistic regression models comparing the haplotype GG with other haplotypes. Significant values () and related OR (95% CI) have been shown in bold.
