Tissue Inhibitor of Metalloproteinase-2 Polymorphisms and Risk for HIV-Associated Neurocognitive Disorder
Table 7
Frequency distribution of TIMP-2 (-418G/C and 303G/A) genotypes in alcohol using HIV patients with and without HAND.
HIV patients with HAND
Genotypes TIMP-2 -418G/C
Alcohol users
Nonusers
value
OR (95% CI)
(%)
(%)
GG
6 (54.5%)
25 (69.1%)
1
(Reference)
GC
3 (27.3%)
12 (30.8%)
0.83
1.20 (0.23-6.31)
CC
2 (18.2%)
2 (5.1%)
0.19
4.83 (0.47-50.04)
Genotypes TIMP-2 303G/A
Alcohol users
Nonusers
P value
OR (95% CI)
(%)
(%)
GG
6 (54.5%)
25 (64.1%)
1
(Reference)
GA
4 (36.4%)
13 (33.3%)
0.43
1.91 (0.38-9.57)
AA
1 (9.1%)
1 (2.6%)
0.23
6.58 (0.31-137.56)
HIV patients without HAND
Genotypes TIMP-2 -418G/C
Alcohol users
Nonusers
value
OR (95% CI)
(%)
(%)
GG
20 (69.0%)
36 (64.3%)
1
(Reference)
GC
2 (6.9%)
14 (25.0%)
0.16
0.30 (0.057-1.61)
CC
7 (24.1%)
6 (10.7%)
0.31
2.03 (0.52-7.95)
Genotypes
Alcohol users
Non-users
value
OR (95% CI)
(%)
(%)
TIMP-2 303G/A
GG
20 (69.0%)
42 (75.0%)
1
(Reference)
GA
9 (31.0%)
14 (25.0%)
0.35
1.72 (0.55-5.34)
AA
0 (0.0%)
0 (0.0%)
NS
NS
= number of subjects, (%) = frequency of subjects; odds ratios and 95% CIs were derived from logistic regression models comparing the homozygous wild-type genotype (GG genotype for TIMP-2 -418G/C and 303G/A was taken as reference) with other genotypes. Alcohol status in 15 HIV-infected individuals was unknown, therefore excluded from the analysis.
