Mediators of Inflammation in Topical Therapy of Skin Cancers

Figure 3

The dual mechanism of action of IM. (a) Rapid necrotic cell death occurring just hours after its application. (b) Neutrophil-mediated antibody-dependent cellular cytotoxicity occurring days after application of the drug. ADCC: antibody-dependent cellular cytotoxicity; GM-CSF: granulocyte-monocyte colony-stimulating factor; IFN: interferon; IL: interleukin; PK-C: protein kinase C; ROS: reactive oxygen species; TNF: tumor necrosis factor.