Dysregulated T Cell Activation and Aberrant Cytokine Expression Profile in Systemic Lupus Erythematosus

Figure 1

Frequencies of HLA-DR⁺CD3⁺ and ICOS⁺CD3⁺T cells in peripheral blood. Peripheral blood mononuclear cells (PBMCs) from double-stranded DNA (dsDNA)⁺ systemic lupus erythematosus (SLE) patients (), dsDNA^-SLE patients (), and healthy control subjects () were harvested and stained with appropriate flow antibodies, and the expression of HLA-DR⁺CD3⁺ and ICOS⁺CD3⁺ cells was analyzed by flow cytometry. (a, b) Representative dot plots of HLA-DR⁺CD3⁺ T cells (a) and the summarized graph (b) are displayed. (c, d) Representative dot plots (c) and pooled data (d) of ICOS⁺CD3⁺ T cells are displayed. Each dot in (c, d) represents one subject. , , , NS: no statistical significance.

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