Dysregulated T Cell Activation and Aberrant Cytokine Expression Profile in Systemic Lupus Erythematosus

Figure 2

Expression levels of PD1, TIM3, and TIGIT on blood T leukocytes. PBMCs from dsDNA⁺ systemic lupus erythematosus (SLE) patients (), dsDNA^-SLE patients (), and control subjects () were harvested and stained with appropriate flow antibodies, and the expressions of PD-1, TIM-3, and TIGIT on CD3⁺ T cells were detected by flow cytometry. The flow figures and pooled data for PD-1⁺ CD4⁺ T cells (a), PD-1⁺ CD8⁺ T cells (b), TIM-3⁺CD4⁺ T cells (c), TIM-3⁺ CD8⁺ T cells (d), TIGIT⁺ CD4⁺ T cells (e), and TIGIT⁺ CD8⁺ T cells (f) are shown. Each dot in the statistical graphs represents an individual subject. , , , NS: no statistical significance.

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