Blockade of IL-17A/IL-17R Pathway Protected Mice from Sepsis-Associated Encephalopathy by Inhibition of Microglia Activation

Figure 2

Microglia activation in the hippocampus region was determined by IF at 6 h, 12 h, 24 h, 48 h, and day 7 post surgery. (a) Representative image of the IF assay in the hippocampus. Specimens were stained with CD11b (green), Iba-1 (red), and DAPI (blue). Representative images were merged and analyzed (1 : 200). Mean fluorescence intensity (MFI) of Iba-1 was shown in each image. (b) Summary data of CD11b and Iba-1 expression in the hippocampus region (). vs. sham control; ^# CLP day 7 vs. CLP 48 h.

(a)

(b)