Paneth Cell Ablation Aggravates Pancreatic and Intestinal Injuries in a Rat Model of Acute Necrotizing Pancreatitis after Normal and High-Fat Diet

Figure 2

Effect of high-fat diet on ANP-associated injuries (TJPs and microbiota diversity) caused by retrograde sodium taurocholate infusion. Expression of caudin-1, occludin, and zo-1 as assessed by (a) western blot and (b) immunohistochemistry of the distal ileum. (c) Estimators of intestinal microbiota α-diversity in rats fed a high-fat or standard diet (). (d) Principal component analysis of microbiota β-diversity (). (e) Predicted microbial functional categories of 16S rRNA in fecal samples at 24 h after induction of ANP., , , Student’s -test.

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