Paneth Cell Ablation Aggravates Pancreatic and Intestinal Injuries in a Rat Model of Acute Necrotizing Pancreatitis after Normal and High-Fat Diet

Figure 4

Effects of dithizone on pancreatic and intestinal injuries in rats on standard diet followed by retrograde sodium taurocholate infusion. (a) Pancreas and distal ileum sections of rats treated with dithizone or saline. Tissue was stained with H&E (magnification ×200). (b) Histopathological scores of the pancreas and distal ileum. (c) Serum TNFα, IL-1β, supplementary, and IL-17A levels in rats treated with dithizone or saline. (d) DAO activity and serum D-lactate in rats treated with dithizone or saline. (e) Distal ileum sections showing immunostaining for claudin-1, occludin, and zo-1, together with quantification of claudin-1, occludin, and zo-1 staining. (f) Expression of claudin-1, occludin, and zo-1 as assessed by western blot. , , , Student’s -test. Results were expressed as the ().

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