Paneth Cell Ablation Aggravates Pancreatic and Intestinal Injuries in a Rat Model of Acute Necrotizing Pancreatitis after Normal and High-Fat Diet

Figure 6

Effects of dithizone on microbiota composition in rats on standard diet followed by retrograde sodium taurocholate infusion. (a) Bacterial phyla and genera with significantly different abundance in rats treated with dithizone or saline. , , , Wilcoxon test. (b) Heatmap showing correlation among SCFAs, lysozyme expression, intestinal barrier dysfunction, serum lipid, pathological changes, and gut microflora. Blue indicates a negative correlation, while red indicates a positive correlation. , , , Spearman test. (c) Analysis of linear discriminant analysis effect size (LEfSe) using multilevel species hierarchy tree and LEfSe bars determined by linear discriminant analysis (LDA). for each group.

(a)

(b)

(c)