Paneth Cell Ablation Aggravates Pancreatic and Intestinal Injuries in a Rat Model of Acute Necrotizing Pancreatitis after Normal and High-Fat Diet

Figure 7

Effects of dithizone on pancreatic and intestinal injuries in rats on high-fat diet followed by retrograde sodium taurocholate infusion. (a) Sections of the pancreas and the distal ileum stained with H&E in rats treated with dithizone or saline (magnification ×200). (b) Histopathological scores of the pancreas and distal ileum. (c) Serum inflammatory cytokines in rats treated with dithizone or saline. (d) DAO activity and serum D-lactate in rats treated with dithizone or saline. (e) Sections of distal ileum showing immunostaining for claudin-1, occludin, and zo-1 in rats treated with dithizone or saline, together with quantification of claudin-1, occludin, and zo-1 immunostaining. (f) Expression of intestinal epithelial TJPs as assessed by western blot. , , , Student’s -test. Results were expressed as the ().

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