Review Article
The Role of Long-Chain Fatty Acids in Inflammatory Bowel Disease
Table 2
Effects of LCFAs on immunity cells in IBD.
| Effects of LCFAs on immune cells | The type of LCFAs | Role |
| Neutrophils | n-6 PUFAs | Inhibit neutrophil infiltration | DHA and EPA | Inhibit neutrophil infiltration | n-3 PUFAs | Avert the concomitant hurt caused by neutrophil production | Dendritic cells | n-3 PUFAs | Reduce the antigen-presenting ability of DCs | PGE2 | Promote the antigen-presenting ability of DCs | B cells | Palmitic acid and oleic acid | Reduce the immune response ability of B cells | n-3 PUFAs | Reduce the immune response ability of B cells, promote intestinal sIgA secretion | T cells | DFO | Reduce the percentage of CD8+ cells, diminish the expression of CD69 on CD4+ T cells, and increase the count of FoxP3+ CD25+ T cells | n-3 PUFAs | Reduce the activated cytokines of Th17 cells | Eicosanoids | Decrease the percentage of Th17 cells |
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