Melatonin Inhibits Lipopolysaccharide-Induced Inflammation and Oxidative Stress in Cultured Mouse Mammary Tissue

Figure 2

Effect of melatonin on inflammatory cytokine and chemokine expression in LPS-stimulated mouse mammary tissue. (a) Effect of melatonin on TNF-α expression. (b) Effect of melatonin on IL-1β expression. (c) Effect of melatonin on IL-6 expression. (d) Effect of melatonin on CXCL1 expression. (e) Effect of melatonin on MCP-1 expression. (f) Effect of melatonin on RANTES expression. Control: containing ethanol as the solvent at the same concentration used in the tests. LPS: a working concentration 100 ng/mL LPS. Mel: a working concentration 10 μg/mL melatonin. LPS+Mel: final concentrations of 100 ng/mL LPS and 10 μg/mL melatonin. Values with different letters differ significantly (P < 0.05).

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