IL-10 Dampens the Th1 and Tc Activation through Modulating DC Functions in BCG Vaccination
The chart of BCG vaccination and challenge to establish the BCG vaccine/challenge mouse model. The IL-10KO and WT mice were housed for 2 weeks after arriving. For vaccination, the mice were intravenously injected with CFU BCG in 200 μL PBS; the control group was given PBS only. For challenge, at D21 after vaccination, the mice were infected intranasally with CFU BCG. The immune responses were detected after 21 days.