LincRNA Cox-2 Regulates Lipopolysaccharide-Induced Inflammatory Response of Human Peritoneal Mesothelial Cells via Modulating miR-21/NF-κB Axis
Effect of Cox-2 suppression on ameliorating LPS induced HPMCs injury. (a) qPCR analysis of the interference effect of sh-RNA on expression of Cox-2 in HPMCs. (b) Cox-2 suppression markedly reversed the reduced cell viability induced by LPS in HPMCs. (c) Cox-2 suppression markedly inhibited the cell apoptosis induced by LPS in HPMCs. (d) Cell apoptosis analyzed by Flow cytometry. (e) The expression of apoptosis-associated proteins after different transfections. (f) The concentration of inflammatory factors in supernatant of HPMCs after different transfections. The experiments were repeated in triplicate. Significance: and versus the controls.