Mediators of Inflammation

Review Article

Implication of IL-17 in Bone Loss and Structural Damage in Inflammatory Rheumatic Diseases

Table 1

Summary of the main findings of IL-17 implication in bone loss and structural damage in animal models.


References	Animal	Animal model	Treatment/intervention	Main results

[22, 23]	IL-17A^-/- mice C57BL/6J mice	NA		IL-17A^-/- mice have physiological bone homeostasis indistinguishable from Wnt mice
[14]	IL-17 overexpression C57BL/6J mice		Systemic recombinant minicircle injection	Peripheral joint destruction without joint inflammation but some psoriasis Systemic bone loss not studied
	IL-17 overexpression C57BL/6J mice	Collagen-induced arthritis	Systemic recombinant minicircle injection	IL-17A exacerbates synovial inflammation and bone loss in inflammatory arthritis
[25]	IL-17RA^-/- mice	Ovariectomy	NA	Protected against bone loss
[24]	Adult Balb/c mice	Ovariectomy	Anti-IL-17 antibody	Prevented the bone loss phenotypes
[26]	Adult Balb/c mice	Ovariectomy	Anti-IL-17, anti-TNF, and anti-RANK-L antibodies	Cortical bone parameters, bone biomechanical properties, and histomorphometry were best preserved by anti-IL-17 antibody
[55]	Balb/c mice	Defects in middiaphysis region of femur	Anti-IL-17 antibody	Improvement of bone healing by recruitment of osteoprogenitors at the injury site
[20]	Sprague-Dawley rats	Critical-sized defects in the calvaria	Defects were filled with IL-17	IL-17 significantly inhibited the filling of calvarial defects in vivo
[43]	DBA/1 mice	Collagen-induced arthritis	Adenoviral IL-17 injected in the knee joint	Accelerated the onset and aggravated the synovial inflammation at the site, enhanced osteoclastic activity
[45]	DBA/1 mice	Collagen-induced arthritis	IL-17-deficient allogeneic bone marrow transplantation	Decreased arthritis severity associated with increased functionally suppressive Tregs and reduced levels of other Th17-lineage inflammatory cytokines
[44]	DBA/1 mice	Collagen-induced arthritis	Anti-IL-17 antibody	Treatment even after the onset of CIA significantly reduced the severity of CIA and suppressed joint damage