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References | Animal | Animal model | Treatment/intervention | Main results |
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[22, 23] | IL-17A-/- mice C57BL/6J mice | NA | | IL-17A-/- mice have physiological bone homeostasis indistinguishable from Wnt mice |
[14] | IL-17 overexpression C57BL/6J mice | | Systemic recombinant minicircle injection | Peripheral joint destruction without joint inflammation but some psoriasis Systemic bone loss not studied |
| IL-17 overexpression C57BL/6J mice | Collagen-induced arthritis | Systemic recombinant minicircle injection | IL-17A exacerbates synovial inflammation and bone loss in inflammatory arthritis |
[25] | IL-17RA-/- mice | Ovariectomy | NA | Protected against bone loss |
[24] | Adult Balb/c mice | Ovariectomy | Anti-IL-17 antibody | Prevented the bone loss phenotypes |
[26] | Adult Balb/c mice | Ovariectomy | Anti-IL-17, anti-TNF, and anti-RANK-L antibodies | Cortical bone parameters, bone biomechanical properties, and histomorphometry were best preserved by anti-IL-17 antibody |
[55] | Balb/c mice | Defects in middiaphysis region of femur | Anti-IL-17 antibody | Improvement of bone healing by recruitment of osteoprogenitors at the injury site |
[20] | Sprague-Dawley rats | Critical-sized defects in the calvaria | Defects were filled with IL-17 | IL-17 significantly inhibited the filling of calvarial defects in vivo |
[43] | DBA/1 mice | Collagen-induced arthritis | Adenoviral IL-17 injected in the knee joint | Accelerated the onset and aggravated the synovial inflammation at the site, enhanced osteoclastic activity |
[45] | DBA/1 mice | Collagen-induced arthritis | IL-17-deficient allogeneic bone marrow transplantation | Decreased arthritis severity associated with increased functionally suppressive Tregs and reduced levels of other Th17-lineage inflammatory cytokines |
[44] | DBA/1 mice | Collagen-induced arthritis | Anti-IL-17 antibody | Treatment even after the onset of CIA significantly reduced the severity of CIA and suppressed joint damage |
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