Identification of the Transcriptional Networks and the Involvement in Angiotensin II-Induced Injury after CRISPR/Cas9-Mediated Knockdown of Cyr61 in HEK293T Cells

Figure 2

Volcano plots and heat map. Volcano plots of all the detected lncRNAs (a) and mRNAs (b) in the control group and downregulated Cyr61 group. The red- and green-dotted lines represent values and multiple screening thresholds, respectively. The blue plots represent significantly changed genes with ≥1.0-fold change and values of 0.05. The heat map displayed differentially expressed mRNAs. (c). Each column represents a sample, and each row represents a dysregulated RNA transcript. The red and green stripes imply that the RNA was upregulated and downregulated, respectively, in the downregulated Cyr61 sample.

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(b)

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