Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein

Figure 1

The macrophages of hypertensive animals have a predisposition toward the M2 phenotype. Four mice for each group, 6 wells per animal. (a) CD86 gene expression. Values were expressed as the . compared to M0 groups and ^# relative to IL-4+IL-13 groups, with ANOVA followed by Bonferroni correction for multiple comparisons. (b) CD206 gene expression. Values expressed as the . compared to M0 groups, ^# relative to LPS+IFN-γ groups, and ^§§ compared to IL-4+IL-13 from control mice, with ANOVA followed by Bonferroni correction for multiple comparisons. (c) Ratio M2/M1. Values are expressed as the . compared to the control group with the -test. The M2/M1 ratio reached 288%.

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