Immune Mediator Profile in Aqueous Humor Differs in Patients with Primary Acquired Ocular Toxoplasmosis and Recurrent Acute Ocular Toxoplasmosis
Table 2
Chemokine, growth factor, angiogenetic factor, and wound healing factor concentration in aqueous humor of a control group and patients with pOT and rOT ().
Immune mediator
Mdn concentration in patients with pOT, (IQR) (pg/ml)
Mdn concentration in patients with rOT, (IQR) (pg/ml)
Mdn concentration in patients in the control group, (IQR) (pg/ml)
pOT vs control value
rOT vs control value
pOT vs rOT value
T cell development-promoting cytokine
IL-2
183 (0, 315)
123 (0, 233)
0 (0, 0)
<0.001
0.003
0.324
Th1-cytokines
IFN-γ
760 (218, 2.93103)
348 (62.7, 909)
0 (0, 0)
<0.0001
<0.001
0.129
TNF-α
55.2 (15.6, 111.4)
22.6 (4.53, 64.9)
0 (0, 0)
<0.00001
<0.001
0.104
Th1 cell development-promoting cytokines
IL-12p70
233 (114, 423)
132 (81.2, 289)
192 (158, 384)
0.761
0.205
0.241
IL-7
654 (464, 1.19103)
450 (318, 937)
772 (532, 851)
0.916
0.097
0.028
IL-15
79.8 (39.9, 217)
47.5 (12.5, 136.5)
0 (0, 23.4)
<0.0001
0.004
0.084
Th2 cytokines
IL-4
29.4 (4.48, 59.6)
16.2 (0, 38.6)
0 (0, 0)
<0.0001
<0.001
0.183
IL-5
49.2 (22.8, 149)
37.1 (15.5, 93.6)
0 (0, 0)
<0.0001
<0.001
0.380
IL-9
135 (58.7, 345)
93.5 (14.9, 205)
0 (0, 0.62)
<0.00001
0.001
0.054
IL-10
67.9 (2.43, 176)
19.8 (0, 102)
1.99 (1.59, 49.8)
0.106
0.521
0.188
IL-13
345.4 (204, 1.05103)
194 (77.9, 647)
230 (103, 286)
0.022
0.402
0.051
Th17 cytokines
IL-17
79.9 (0, 371)
0 (0, 234)
0 (0, 0)
0.001
0.014
0.237
IL-1Rα
262 (53.5, 648)
130 (0, 337)
0 (0, 0)
<0.0001
0.002
0.207
Th17 cell development-promoting cytokines
IL-6
2.74103 (738, 6.01103)
1.06103 (173, 3.99103)
150 (1.54, 409)
<0.0001
0.004
0.108
IL-1β
3.96 (0.57, 8.11)
1.38 (0, 5.36)
0 (0, 1.49)
0.003
0.032
0.220
pOT: primary OT; rOT: recurrent OT: Mdn: median; IQR: interquartile range; significant values are shown in bold; italic values are below LLOQ as defined by the manufacturer.
