Immune Mediator Profile in Aqueous Humor Differs in Patients with Primary Acquired Ocular Toxoplasmosis and Recurrent Acute Ocular Toxoplasmosis

Table 3

Chemokines, growth factor, angiogenetic factor, and wound healing factor concentrations in aqueous humor of a control group and patients with pOT and rOT ().

Immune mediator	Mdn concentration in patients with pOT, (IQR) (pg/ml)	Mdn concentration in patients with rOT, (IQR) (pg/ml)	Mdn concentration in patients in the control group, (IQR) (pg/ml)	pOT vs control value	rOT vs control value	pOT vs rOT value
Chemokines
MIP-1α	271 (134, 412)	157 (56.7, 451)	0 (0, 41.2)	<0.0001	<0.001	0.331
MIP-1β	396 (299, 604)	283 (178, 593)	218 (166, 341)	0.023	0.210	0.153
IP-10	5.9710^5 (7.9310^4, 9.3810^5)	1.5210^5 (2.7510^4, 7.9910^5)	5.7510^3 (3.1710^3, 13.010^4)	<0.00001	<0.0001	0.235
Eotaxin	925 (241, 1.3210^3)	755 (0, 1.0110^3)	1.95 (0, 290)	<0.001	0.007	0.302
IL-8	280 (128, 937)	120 (51.6, 611)	56.5 (0, 90.2)	<0.001	0.009	0.166
RANTES	219 (61.3, 296)	91.1 (7.4, 372)	0 (0, 0)	<0.0001	<0.001	0.366
PDGF-bb	288 (63.8, 598)	164 (0, 419)	0 (0, 0)	<0.001	0.001	0.378
Growth, angiogenetic, and wound healing factors
GM-CSF	0 (0, 169)	0 (0, 98.7)	0 (0, 0)	0.036	0.067	0.639
G-CSF	513 (68.8, 1.7610^3)	195 (5.37, 999)	0 (0, 435)	0.004	0.034	0.258
MCP-1	2.1310^3 (1.1410^3, 5.4510^3)	1.4810^3 (1.0510^3, 2.4110^3)	958 (667, 1.3410^3)	<0.001	0.009	0.151
VEGF	1.1310^3 (394, 1.7810^3)	908 (246, 1.8510^3)	1.2910^3 (828, 1.6810^3)	0.746	0.469	0.637
FGF basic	38.2 (2.87, 80.6)	27.6 (0.67, 60.4)	0 (0, 57.5)	0.066	0.245	0.333

pOT: primary OT; rOT: recurrent OT, Mdn: median, IQR: interquartile range: significant values are shown in bold; italic values are below LLOQ as defined by the manufacturer.