IL18 Polymorphism and Periodontitis Susceptibility, Regardless of IL12B, MMP9, and Smoking Habits

Table 2

Genotype and allele frequency distributions of the IL12, IL18 and MMP9 in the CP and nonsmoking CP patients compared to their respective controls.

		All subjects		Nonsmokers
		CP patients	Controls	CP patients	Controls
		(%)	(%)	(%)	(%)			OR (95% CI)	AIC
IL18
137G>C
(rs187238)	G/G	91 (48)	97 (52)	48 (44)	75 (54)
Genotype	G/C	85 (44)	70 (38)	54 (50)	48 (35)
	C/C	15 (8)	18 (10)	7 (6)	15 (11)
	G/G+C/C	106 (56)	115 (62)	55 (50)	90 (65)	ref
	G/C	85 (44)	70 (38)	54 (50)	48 (35)	0.01	0.03	1.99 (1.17-3.36)	330.7
Allele	G	267 (70)	264 (71)	150 (69)	198 (72)
	C	115 (30)	106 (29)	68 (31)	78 (28)
IL18
607A>C
(rs1946518)	A/A	43 (22)	35 (19)	29 (26)	27 (19)
Genotype	A/C	93 (49)	82 (44)	50 (46)	61 (44)
	C/C	56 (29)	70 (37)	31 (28)	52 (37)
Allele	A	179 (47)	152 (41)	108 (49)	115 (41)
	C	205 (53)	222 (59)	112 (51)	165 (59)
IL12B
1188A>C
(rs3212227)	A/A	63 (49)	66 (51)	40 (51)	59 (52)
Genotype	A/C	49 (38)	53 (40)	27 (35)	46 (40)
	C/C	16 (12)	12 (9)	11 (14)	9 (8)
Allele	A	175 (68)	185 (71)	107 (69)	164 (72)
	C	81 (32)	77 (29)	49 (31)	64 (28)
MMP9
1562C>T
(rs3918242)	C/C	150 (80)	142 (77)	78 (77)	111 (78)
Genotype	C/T	37 (20)	40 (21)	23 (23)	29 (20)
	T/T	1 (1)	3 (2)	0 (0)	2 (2)
Allele	C	337 (90)	324 (88)	179 (89)	251 (88)
	T	39 (10)	46 (12)	23 (11)	33 (12)

: number; ref: reference; OR: odds ratio; : value; CP: chronic periodontitis; AIC: Akaike information criteria. IL18-137G/C genotype: CP patient vs. control in the nonsmoking group.