IL-37 Exerts Anti-Inflammatory Effects in Fetal Membranes of Spontaneous Preterm Birth via the NF-κB and IL-6/STAT3 Signaling Pathway

Figure 5

IL-37 exerts its biological functions through the NF-κB and IL-6/STAT3 signaling pathway. (a) The phosphorylation of NF-κB, STAT3, and total amounts of NF-κB, STAT3 were detected by western blot after administrated by LPS and LPS+rhIL-37 for 12 hours. (b) Densitometry quantifications of p-NF-κB to T-NF-κB and p-STAT3 to T-STAT3 level were shown. (c) Western blot analysis of p-STAT3 and T-STAT3 expression was presented following treatment with rhIL-6 and rhIL-37+rhIL-6 for 12 hours. (d) Densitometry quantification of p-STAT3 to T-STAT3 level was demonstrated. vs. LPS; vs. rhIL-6; ^## vs. control.

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