Research Article
Inhibition of the ROS-EGFR Pathway Mediates the Protective Action of Nox1/4 Inhibitor GKT137831 against Hypertensive Cardiac Hypertrophy via Suppressing Cardiac Inflammation and Activation of Akt and ERK1/2
Figure 2
Nox1/4 inhibitor GKT137831 inhibited cardiac fibrosis in spontaneously hypertensive rats. (a) Representative microphotographs of Masson staining of the heart. (b) Fibrosis area ( per group). (c) Col I-positive area ( per group). (d) Representative microphotographs of immunochemistry for Col I and Col III. (e) Col III-positive area ( per group). (f) mRNA levels of Col I and Col III in the left ventricle ( per group). SHR represents spontaneously hypertensive rats, Col I represents collagen I, and Col III represents collagen III. # vs. the control group; vs. the SHR group.
(a) |
(b) |
(c) |
(d) |
(e) |
(f) |