Research Article
Inhibition of the ROS-EGFR Pathway Mediates the Protective Action of Nox1/4 Inhibitor GKT137831 against Hypertensive Cardiac Hypertrophy via Suppressing Cardiac Inflammation and Activation of Akt and ERK1/2
Figure 3
Nox1/4 inhibitor GKT137831 reduced reactive oxygen species (ROS) production and epidermal growth factor receptor (EGFR) activation in the left ventricle of spontaneously hypertensive rats. (a) H2O2 level ( per group). (b) MDA level ( per group). (c) EGFR activity ( per group). SHR represents spontaneously hypertensive rats; H2O2 represents hydrogen peroxide; MDA represents malondialdehyde. # vs. the control group; vs. the SHR group.
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