Inhibition of the ROS-EGFR Pathway Mediates the Protective Action of Nox1/4 Inhibitor GKT137831 against Hypertensive Cardiac Hypertrophy via Suppressing Cardiac Inflammation and Activation of Akt and ERK1/2

Table 1

Effect of Nox1/4 inhibitor GKT137831 on echocardiographic and hemodynamic parameters in spontaneously hypertensive rats.

	Control	SHR	SHR+GKT137831
LVAWd (mm)		^#
LVAWs (mm)		^#
LVPWd (mm)		^#
LVPWs (mm)		^#
LVIDd (mm)
LVIDs (mm)
Fractional shortening (%)
Ejection fraction (%)
AoSP (mmHg)		^#
AoDP (mmHg)		^#
Heart rate (beats/min)
max (mmHg/s)		^#
min (mmHg/s)		^#

SHR represents spontaneously hypertensive rats. LVAWd: left ventricular anterior wall thickness during diastole; LVAWs: left ventricular anterior wall thickness during systole; LVPWd: left ventricular posterior wall thickness during diastole; LVPWs: left ventricular posterior wall thickness during systole; LVIDd: left ventricular internal diameter during diastole; LVIDs: left ventricular internal diameter during systole; AoSP: aortic systolic pressure; AoDP: aortic diastolic pressure; max: the maximal rate of left ventricular pressure increase; min: the maximal rate of left ventricular pressure decrease. Data are expressed as , . One-way ANOVA followed by post hoc test was carried out for the statistical analyses. ^# vs. the control group; vs. the SHR group.