Exploring the Mechanism on the Medullary Visceral Zone Inhibiting the Cholinergic Anti-inflammatory Pathway Induced by Sepsis

Figure 3

The concentration of serum proinflammatory cytokines among the groups of rats. sCD14: soluble CD14; precepsin; HMGB-1: high mobility group box-1; IL-10: interleukin 10; TNF-α: tumor necrosis factor alpha; IL-1α: interleukin 1 alpha; IL-6: interleukin 6. (a) The serum sCD14 concentration (ng/mL) among different groups; it is a marker of inflammation in the late stage of sepsis. (c) Serum concentration of IL-10, TNF-α, IL-1α, and IL-6 (pg/mL) among groups. The serum sCD14 levels of the model group, GTS-21 group, and MLA group were much higher than those of the control group. The value and 95% CI were, respectively, 0.000, -286.858∼-79.4662; 0.44, -209.616∼-2.223; and 0.000, 400.647∼-193.255, and so were HMGB1, TNF-α, IL-10, and IL-6. For HMGB1, they were 0.000, -766.215∼-289.627; 0.012, -527.403∼-50.815; and 0.000, -917.862∼-441.275. For TNF-α, they were 0.000, -139.923∼-82.198; 0.000, -104.224∼-46.494; and 0.000, 175.466. For IL-1α, they were 0.000, -102.305∼-57.714; 0.000, -66.369∼-21.777; and 0.000, -121.697∼-77.106. For IL-10, they were 0.000, -83.572∼-32.005; 0.006, -59.758∼-8.191; and 0.000, -108.319∼-56.752. For IL-6, they were 0.000, -77.851∼-42.647; 0.000-59.996∼-24.792; and 0.000, -87.186∼-51.982. The serum sCD14, HMGB1, TNF-α, IL-1α, IL-10, and IL-6 levels of the MLA group were much higher than those of rats in the GTS-21 group; the value and 95% CI were, respectively, 0.000, -294.727∼-87.3357; 0.001, 152.166∼628.754; 0.000, 42.107∼99.837; 0.000, 33.033∼77.624; 0.000, 22.777∼74.344; and 0.001, 9.588∼44.792. A: vs. control group; B: vs. model group; C: vs. GTS-21 group.

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