IL-33 Inhibits Hepatitis B Virus through Its Receptor ST2 in Hydrodynamic HBV Mouse Model

Figure 1

IL-33 treatment inhibits HBV in the hydrodynamic HBV mouse model in a dose-dependent manner. C57BL/6 mice were injected intraperitoneally with IL-33 (0.1 and 1 μg/mouse) and PBS (1 ml/mouse) daily for 1 week, respectively. The concentrations of HBsAg, HBeAg, and HBV DNA in the serum of HBV mice (a). Images of HBcAg staining detected by histological study in liver sections were from HBV mice (b). The levels of ALT and AST and cholinesterase in the serum HBV mice (c). The statistical significance of the data was determined using the Mann–Whitney test; value is shown in each test.

(a)

(b)

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