Research Article
Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway
Figure 5
CD137-enhanced aortic sprouting and outspreading through the VEGFR2/Akt/eNOS pathway. (a) The sprouting of aortic rings under the CD137 activation or/and inhibition of VEGFR2 with XL184 (cabozantinib). (b) Number of sprouts per ring was quantified by Image-Pro Plus 8.0, . (c) Aortic rings sprouting after treatment with VEGFR2 siRNA or/and LY294002 under the CD137 activation. (d) Number of sprouts per ring was quantified by Image-Pro Plus 8.0, . , .
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