Expression of AIM2 in Rheumatoid Arthritis and Its Role on Fibroblast-Like Synoviocytes

<div>The differences in AIM2 pathway-related molecules in synovium among OA and RA. mRNA AIM2 and AIM2 pathway-related proteins including ASC and IL-1<i>β</i> were expressed higher in RA than in OA; caspase-1 was higher in RA than in OA without statistical significance (a). <svg height="8.68572pt" id="M56" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 11.0606 8.68572" width="11.0606pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M828 650H570L564 622C646 614 650 609 634 524L604 366H253L281 524C296 608 308 615 382 622L388 650H132L126 622C211 615 214 609 198 524L121 122C106 42 102 35 23 28L17 0H276L282 28C196 35 191 40 206 122L243 324H597L559 123C544 42 537 35 452 28L446 0H710L716 28C632 35 628 43 643 122L719 524C735 610 741 615 822 622L828 650Z"></path></g></svg> score for the synovium of RA, AIM2, and AIM2 pathway-related proteins including ASC, caspase-1, and IL-1<i>β</i> was more expressed than that of OA (b). <span class="nowrap"><svg height="13.532pt" id="M57" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 50.6052 13.532" width="50.6052pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 158Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.079,0)"><path 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Mediators of Inflammation

fig2

Figure 2

Figure 2: Expression of AIM2 in Rheumatoid Arthritis and Its Role on Fibroblast-Like Synoviocytes 