Expression of AIM2 in Rheumatoid Arthritis and Its Role on Fibroblast-Like Synoviocytes

Figure 5

Proliferation, apoptosis, and migration assay of RA-FLS after si-AIM2 transfection. AIM2 and its downstream proteins including ASC, caspase-1, and IL-1β were successfully silenced after 24 h of transfection (a). Western blot confirmed the successful silencing of the AIM2 expression by si-AIM2 (b). The proliferation of RA-FLS was inhibited after 48 h of transfection (c). There were no significant differences between the NC and si-AIM2 groups in apoptosis and migration assay (d, e). , , , and .

(a)

(b)

(c)

(d)

(e)