Antagonistic Peptides That Specifically Bind to the First and Second Extracellular Loops of CCR5 and Anti-IL-23p19 Antibody Reduce Airway Inflammation by Suppressing the IL-23/Th17 Signaling Pathway

<div>Effects of peptides of CCR5 and anti-IL-23p19 mAb on the number of Th17 cells positively produced. (a) Representative results of the percentage of the Th17 cells in the CD3<sup>+</sup>CD4<sup>+</sup> gate of the spleen compared the (i) control, (ii) sensitization, (iii) model, (iv) anti-IL-23p19, (v) GH, (vi) HY, and (vii) anti-IL-23p19 with HY groups, as analyzed by using flow cytometry. (vii) The FMO control of IL-17 staining. (b) Histogram showing the proportion of Th17 cells in the thymus, spleen, and peripheral blood. 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Mediators of Inflammation

fig5

Figure 5

Figure 5: Antagonistic Peptides That Specifically Bind to the First and Second Extracellular Loops of CCR5 and Anti-IL-23p19 Antibody Reduce Airway Inflammation by Suppressing the IL-23/Th17 Signaling Pathway 

Figure 5 | Antagonistic Peptides That Specifically Bind to the First and Second Extracellular Loops of CCR5 and Anti-IL-23p19 Antibody Reduce Airway Inflammation by Suppressing the IL-23/Th17 Signaling Pathway 