Pain Mechanism in Rheumatoid Arthritis: From Cytokines to Central Sensitization

Table 2

Summarized studies showing the dual role of ion channels in RA pain.

Ion channels	Pharmacological interventions/transgenic animals	Effects	Reference
Ca^2+channels	Blocking calcium channel	Reduce mechanical hyperalgesia	88, 89, 90
TRPV1	Neutralization of TRPV1	Reduce mechanical hyperalgesia	91
	TRPV1^-/- mice	Reduced late mechanical hyperalgesia	92
	Application of TRPV1 antagonists	Do not reduce mechanical hyperalgesia	94
ASIC3	ASIC3^-/- mice	Reduced late mechanical hyperalgesia	92