Disease-Specific Autoantibodies Induce Trained Immunity in RA Synovial Tissues and Its Gene Signature Correlates with the Response to Clinical Therapy

<div>cIgG-trained signatures correlate with clinical response to infliximab therapy. Analysis of synovial tissue transcriptome from 62 RA patients in GSE21537 before the initiation of infliximab (anti-TNF<i>α</i> treatment). The clinical outcome by infliximab at 16 weeks was defined by EULAR response criteria. Scores versus EULAR responses are plotted for (a) cIgG-trained scores and the synovial (b) myeloid, (c) lymphoid, and (d) fibroid pathotypes. The Kruskal–Wallis test was performed, followed by post hoc testing by Dunn’s multiple comparison test.</div>

Mediators of Inflammation

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Figure 7: Disease-Specific Autoantibodies Induce Trained Immunity in RA Synovial Tissues and Its Gene Signature Correlates with the Response to Clinical Therapy 

Figure 7 | Disease-Specific Autoantibodies Induce Trained Immunity in RA Synovial Tissues and Its Gene Signature Correlates with the Response to Clinical Therapy 