Mediators of Inflammation

Clinical Study

Elevated Circulating Fetuin-B Levels Are Associated with Insulin Resistance and Reduced by GLP-1RA in Newly Diagnosed PCOS Women

Table 1

Main clinical features and serum Fetuin-B concentrations in PCOS and healthy women.


Variable	PCOS ()	Controls ()	value

Age (years)			NS
BMI (kg/m²)			<0.01
FAT (%)			<0.01
WHR			<0.01
SBP (mmHg)			<0.01
DBP (mmHg)			<0.01
TC (mmol/L)			<0.01
TG (mmol/L)			<0.01
HDL-C (mmol/L)			NS
LDL-C (mmol/L)			<0.01
FFAs (μmol/L)			NS
FBG (mmol/L)			<0.01
2 h-BG (mmol/L)	7.82 (6.33-9.25)	5.43 (4.71-6.32)	<0.01
FIns (mU/L)	18.42 (11.34-27.34)	7.12 (5.96-8.72)	<0.01
2 h-Ins (mU/L)	150.8 (99.1-249.6)	41.9 (24.3-68.7)	<0.01
value (mg/kg/min)			<0.01
^§ value			<0.01
HOMA-_IR	4.38 (2.64-6.95)	1.41 (1.15-1.81)	<0.01
^§HOMA-_IR			<0.05
AUCi (mU × h/L)	274.6 (194.6-397.5)	111.1 (73.0-146.6)	<0.01
AUCg (mmol × h/L)	17.12 (14.82-18.90)	11.98 (10.92-13.89)	<0.01
Fetuin-B (mg/L)			<0.01
^§Fetuin-B			<0.05
DHEA-S (μg/dL)			<0.01
LH (IU/L)			NS
FSH (IU/L)			<0.01
Estradiol (pg/mL)	44.2 (33.7-57.8)	44.4 (29.0-63.9)	NS
Prolactin (μg/L)			NS
Prog (nmol/L)	1.67 (1.04-2.58)	2.18 (1.41-3.12)	NS
SHBG (nmol/L)	35.2 (24.9-49.5)	61.3 (77.6-45.3)	<0.01
TEST (nmol/L)			<0.01
FAI			<0.01

BMI: body mass index; FAT (%): the percentage of body fat; WHR: waist-to-hip ratio; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; FFAs: free fatty acids; FBG: fasting blood glucose; 2 h-BG: 2 h blood glucose after glucose overload; FIns: fasting insulin; 2 h-Ins: 2 h insulin after glucose overload; HOMA-_IR: HOMA-insulin resistance index; AUCi: the area under the curve for insulin; AUCg: the area under the curve for glucose; . LH: luteinizing hormone; FSH: follicle-stimulating hormone; DHEA-S: dehydroepiandrosterone-sulfate; SHBG: sex hormone-binding globulin; TEST: testosterone; Prog: progesterone. Values were given as or median (interquartile Range). Values were given as or median (interquartile Range). ^§ by a general linear model with adjustment of age and BMI.