P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion
Control of L. amazonensis infection by UTP requires CASP-1,11. (a) Schematics showing the infection and treatments. Representative images of infected peritoneal macrophages from WT (b, c) and CASP-1,11-/- (d, e) treated with UTP (100 μM) (d, e) for 30 min or left untreated (b, c). The antiparasitic effect of UTP treatment was evaluated through the “infection index” (f). Data represent of three independent experiments performed in triplicate, with pools of 3–4 animals in each experiment. relative to the untreated group (one-way analysis of variance followed by Tukey’s test).
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