Research Article
Pirfenidone Inhibits Hypoxic Pulmonary Hypertension through the NADPH/ROS/p38 Pathway in Adventitial Fibroblasts in the Pulmonary Artery
Figure 4
PFD treatment reduced hypoxia-induced p38 phosphorylation in HPAAFs. (a, b) Hypoxia increased the phosphorylation of p38, while preincubation with p38 inhibitor (SB203580, 5 mM) reduced the expression of p-p38 (). (c, d) PFD treatment reduced hypoxia-induced p38 phosphorylation in HPAAFs (). Nor: normoxia; Hyp: hypoxia; SB203580: p38 inhibitor; PFD: pirfenidone; HPAAFs: human pulmonary arterial adventitial fibroblasts.
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