Pirfenidone Inhibits Hypoxic Pulmonary Hypertension through the NADPH/ROS/p38 Pathway in Adventitial Fibroblasts in the Pulmonary Artery

<div>The role of PFD on HPAAFs in hypoxia. In the human pulmonary artery adventitial fibroblasts, PFD reduced hypoxia-induced cell proliferation, migration, and differentiation through the NOX4/ROS/P38 signaling pathway. Meanwhile, there was no direct cross effect between NOX4 and Rac1. PFD: pirfenidone; ROS: reactive oxygen species.</div>

Mediators of Inflammation

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Figure 7

Figure 7: Pirfenidone Inhibits Hypoxic Pulmonary Hypertension through the NADPH/ROS/p38 Pathway in Adventitial Fibroblasts in the Pulmonary Artery 