Perspectives in HPV Secondary Screening and Personalized Therapy Basing on Our Understanding of HPV-Related Carcinogenesis Pathways

<div>pRB role in cell cycle 2. P16 through its inhibiting effect on CDK 4 and 6 prevents phosphorylation of pRB. Hyperphosphorylated pRB cannot bind to E2F and allows it to promote progression to the S phase of the cell cycle.</div>

Mediators of Inflammation

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Figure 2

Figure 2: Perspectives in HPV Secondary Screening and Personalized Therapy Basing on Our Understanding of HPV-Related Carcinogenesis Pathways 