Serum and Cerebrospinal Fluid Cytokine Biomarkers for Diagnosis of Multiple Sclerosis

Table 3

Different model accuracy of MS diagnosis.

Cytokines datasets		Model (accuracy in percentage)
		gNB	KNN	DT	XGB	RF
IL-1α, IL-4, IL-18, CCL7, CCL27, INFγ, LIF, M- CSF, TNF-α, SCF	CSF	≥96	≥93	≥93	≥92	≥92
	Serum	≥95	≥95	≥96	≥96	≥96
IL-1β, IL-2, IL-7, IL-10, IL-9 IL-12(p70), IL-16, CCL3, CCL4, GM-CSF, PDGF-bb, TRAIL	CSF	≥96	99	≥96	≥98	99
IL-8, IL-12p40, CCL2, CCL5, CXCL1, CXCL9, HGF, IFN-α2, b-NGF, SCGF-b	Serum	≥92	≥90	≥92	≥94	≥95

In each cytokine dataset, randomly five cytokines were taken in each model to calculate the accuracy with -fold cross validation. Cytokines found commonly affected in serum and CSF of MS; Cytokines uniquely affected in CSF; Cytokines uniquely affected in serum.