Research Article
Evaluation of the Biomarkers HMGB1 and IL-6 as Predictors of Mortality in Cirrhotic Patients with Acute Kidney Injury
Table 2
Comparison of demographic, clinical, and laboratory variables between survivors and nonsurvivors at 30 days.
| | Survivors () | Nonsurvivors () | value |
| | Demographic | | | | | Age | 56.1 (±10.4) | 54 (±7.7) | 0.709 | | Males | 14 (73.7%) | 2 (50%) | 0.349 | | Females | 5 (26.3%) | 2 (50%) | | Clinical | | | | | Child-Pugh | 10.3 (±1.7) | 12.7 (±1.5) | 0.019 | | MELD | 20.2 (±6.1) | 31.5 (±8.6) | 0.05 | | MELD-Na | 23.1 (±6.4) | 27.6 (±7.3) | 0.015 | | ICA-AKI stage | | | | | 1 | 13 (68.4%) | 2 (50%) | 0.609 | | 2 | 5 (26.3%) | 2 (50%) | | | 3 | 1 (5.3%) | 0 | | | AKI causes | | | | | Infection | 11 (57.9%) | 2 (50%) | 0.822 | | Hypovolemia | 7 (36.8%) | 2 (50%) | | | Hepatorenal syndrome | 0 | 0 | | | Renal disease | 1 (5.3%) | 0 | | | Response to treatment with plasma expanders | | | | | Complete | 12 (63.2%) | 1 (25%) | 0.005 | | Partial | 7 (36.8%) | 1 (25%) | | | Absent | 0 | 2 (50%) | | | Encephalopathy | | | | | Present | 6 (31.6%) | 2 (50%) | 0.589 | | Absent | 13 (68.4%) | 2 (50%) | | | Ascites | | | | | Present | 17 (89.5%) | 4 (100%) | 0.497 | | Absent | 2 (17.1%) | 0 | | | Laboratory | | | | | HMGB1 (pg/mL) | 1174.2 (0.1-6665) | 3338.5 (2273-6851.8) | 0.035 | | IL-6 (pg/mL) | 43.3 (0.1-135.6) | 153.3 (21.1-1107) | 0.061 | | Creatinine (mg/dL) | 2.0 (±0.7) | 1.8 (±0.1) | 0.663 | | Total bilirubin (mg/dL) | 1.7 (0.4-15.3) | 6 (4.6-8.0) | 0.168 | | Albumin (g/dL) | 2.5 (±0.4) | 2.4 (±0.6) | 0.481 | | INR | 1.5 (1.0-2.4) | 3.1 (2.0-3.09) | 0.009 | | Sodium (mEq/L) | 133.2 (±5.4) | 134.8 (±4.3) | 0.127 | | C-reactive protein (mEq/L) | 34 (9-287) | 28 (18-46) | 0.626 |
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ICA-AKI: International Club of Ascites-Acute Kidney Injury.
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