Mediators of Inflammation / 2020 / Article / Tab 2

Research Article

Evaluation of the Biomarkers HMGB1 and IL-6 as Predictors of Mortality in Cirrhotic Patients with Acute Kidney Injury

Table 2

Comparison of demographic, clinical, and laboratory variables between survivors and nonsurvivors at 30 days.

Survivors ()Nonsurvivors () value

Demographic
 Age56.1 (±10.4)54 (±7.7)0.709
 Males14 (73.7%)2 (50%)0.349
 Females5 (26.3%)2 (50%)
Clinical
 Child-Pugh10.3 (±1.7)12.7 (±1.5)0.019
 MELD20.2 (±6.1)31.5 (±8.6)0.05
 MELD-Na23.1 (±6.4)27.6 (±7.3)0.015
ICA-AKI stage
 113 (68.4%)2 (50%)0.609
 25 (26.3%)2 (50%)
 31 (5.3%)0
AKI causes
 Infection11 (57.9%)2 (50%)0.822
 Hypovolemia7 (36.8%)2 (50%)
 Hepatorenal syndrome00
 Renal disease1 (5.3%)0
Response to treatment with plasma expanders
 Complete12 (63.2%)1 (25%)0.005
 Partial7 (36.8%)1 (25%)
 Absent02 (50%)
Encephalopathy
 Present6 (31.6%)2 (50%)0.589
 Absent13 (68.4%)2 (50%)
Ascites
 Present17 (89.5%)4 (100%)0.497
 Absent2 (17.1%)0
Laboratory
 HMGB1 (pg/mL)1174.2 (0.1-6665)3338.5 (2273-6851.8)0.035
 IL-6 (pg/mL)43.3 (0.1-135.6)153.3 (21.1-1107)0.061
 Creatinine (mg/dL)2.0 (±0.7)1.8 (±0.1)0.663
 Total bilirubin (mg/dL)1.7 (0.4-15.3)6 (4.6-8.0)0.168
 Albumin (g/dL)2.5 (±0.4)2.4 (±0.6)0.481
 INR1.5 (1.0-2.4)3.1 (2.0-3.09)0.009
 Sodium (mEq/L)133.2 (±5.4)134.8 (±4.3)0.127
 C-reactive protein (mEq/L)34 (9-287)28 (18-46)0.626

ICA-AKI: International Club of Ascites-Acute Kidney Injury.

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