Mediators of Inflammation / 2020 / Article / Tab 3

Research Article

Evaluation of the Biomarkers HMGB1 and IL-6 as Predictors of Mortality in Cirrhotic Patients with Acute Kidney Injury

Table 3

Comparison of demographic, clinical, and laboratory variables between survivors and nonsurvivors at three months.

Survivors ()Nonsurvivors () value

Demographic
 Age55.3 (±11.6)53.9 (±5.7)0.528
 Males17 (65.4%)16 (72.7%)0.584
 Females9 (34.6%)6 (33.3%)
Clinical
 Child-Pugh10.3 (±1.7)11.6 (±2.1)0.134
 MELD20.1 (±6.1)26.9 (±9.8)0.061
 MELD-Na22.3 (±7.0)29.4 (±7.5)0.044
ICA-AKI stage
 112 (80%)2 (28.6%)0.045
 23 (20%)4 (57.1%)
 30 (11.5%)1 (14.3%)
AKI causes
 Infection8 (53.3%)4 (57.1%)0.783
 Hypovolemia6 (40%)3 (42.9%)
 Hepatorenal syndrome00
 Renal disease1 (6.7%)0
Response to treatment with plasma expanders
 Complete10 (66.7%)2 (28.6%)0.059
 Partial5 (33.3%)3 (42.9%)
 Absent02 (28.6%)
Encephalopathy
 Present4 (26.7%)3 (42.9%)0.387
 Absent11 (73.3%)4 (57.1%)
Ascites
 Present13 (86.7%)7 (100%)0.455
 Absent2 (13.3%)0 (9.1%)
Laboratory
 HMGB1 (pg/mL)1540 (0.1-6665)2352 (53.2-6851.8)0.243
 IL-6 (pg/mL)35.8 (0.1-113.5)87.9 (4.4-1107.3)0.071
 Creatinine (mg/dL)1.9 (±0.6)2.4 (±0.8)0.086
 Total bilirubin (mg/dL)1.7 (0.4-15.3)5.37 (0.4-8.3)0.573
 Albumin (g/dL)2.5 (±0.4)2.6 (±0.6)0.525
 INR1.5 (1-2.24)2.0 (1.2-5.0)0.341
 Sodium (mEq/L)133.3 (±4.4)132.8 (±5.5)0.829
 C-reactive protein (mEq/L)30.8 (5-278)31.6 (5-287)0.860

ICA-AKI: International Club of Ascites-Acute Kidney Injury.

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