Research Article
Evaluation of the Biomarkers HMGB1 and IL-6 as Predictors of Mortality in Cirrhotic Patients with Acute Kidney Injury
Table 3
Comparison of demographic, clinical, and laboratory variables between survivors and nonsurvivors at three months.
| | Survivors () | Nonsurvivors () | value |
| | Demographic | | | | | Age | 55.3 (±11.6) | 53.9 (±5.7) | 0.528 | | Males | 17 (65.4%) | 16 (72.7%) | 0.584 | | Females | 9 (34.6%) | 6 (33.3%) | | Clinical | | | | | Child-Pugh | 10.3 (±1.7) | 11.6 (±2.1) | 0.134 | | MELD | 20.1 (±6.1) | 26.9 (±9.8) | 0.061 | | MELD-Na | 22.3 (±7.0) | 29.4 (±7.5) | 0.044 | | ICA-AKI stage | | | | | 1 | 12 (80%) | 2 (28.6%) | 0.045 | | 2 | 3 (20%) | 4 (57.1%) | | 3 | 0 (11.5%) | 1 (14.3%) | | AKI causes | | | | | Infection | 8 (53.3%) | 4 (57.1%) | 0.783 | | Hypovolemia | 6 (40%) | 3 (42.9%) | | | Hepatorenal syndrome | 0 | 0 | | | Renal disease | 1 (6.7%) | 0 | | | Response to treatment with plasma expanders | | | | | Complete | 10 (66.7%) | 2 (28.6%) | 0.059 | | Partial | 5 (33.3%) | 3 (42.9%) | | | Absent | 0 | 2 (28.6%) | | | Encephalopathy | | | | | Present | 4 (26.7%) | 3 (42.9%) | 0.387 | | Absent | 11 (73.3%) | 4 (57.1%) | | | Ascites | | | | | Present | 13 (86.7%) | 7 (100%) | 0.455 | | Absent | 2 (13.3%) | 0 (9.1%) | | | Laboratory | | | | | HMGB1 (pg/mL) | 1540 (0.1-6665) | 2352 (53.2-6851.8) | 0.243 | | IL-6 (pg/mL) | 35.8 (0.1-113.5) | 87.9 (4.4-1107.3) | 0.071 | | Creatinine (mg/dL) | 1.9 (±0.6) | 2.4 (±0.8) | 0.086 | | Total bilirubin (mg/dL) | 1.7 (0.4-15.3) | 5.37 (0.4-8.3) | 0.573 | | Albumin (g/dL) | 2.5 (±0.4) | 2.6 (±0.6) | 0.525 | | INR | 1.5 (1-2.24) | 2.0 (1.2-5.0) | 0.341 | | Sodium (mEq/L) | 133.3 (±4.4) | 132.8 (±5.5) | 0.829 | | C-reactive protein (mEq/L) | 30.8 (5-278) | 31.6 (5-287) | 0.860 |
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ICA-AKI: International Club of Ascites-Acute Kidney Injury.
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